Thursday, April 2nd Edition
Cory Ohlendorf  
By Cory Ohlendorf, Valet. Editor
How long have you had your gmail name? Would you consider changing it?

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Today’s Big Story

The New GLP-1 Pill Is a Big Deal

 

The FDA just approved Foundayo, and kicked off a new front in the weight-loss drug wars

 

U.S. regulators on Wednesday approved Eli Lilly’s GLP-1 pill for sale in the country, opening up a new phase in weight-loss medication. The drug, which will be sold under the brand name Foundayo, will compete with the pill version of Novo Nordisk’s Wegovy, approved in December. But Lilly’s pill is cheaper to manufacture and more convenient to consume, Vox noted.

They say the approval for the drug “marks an important technological inflection point for this class of drugs that is transforming obesity care in America and around the world.” The previous generation of GLP-1 treatments were injections: Patients (or their doctors) had to handle a needle and insert it into their body in order to reap the weight-loss benefits.

With an easier way to take the medications, experts say that the weight-loss pill wars start now. “It will be a battle royal for GLP-1 pill leadership and dominance of the booming $70 billion-plus market for weight-loss and diabetes drugs” one analyst told the Wall Street Journal. He said they’re betting on Lilly, expecting its pill to generate about $21 billion in global sales by 2030—compared with $4 billion for the Wegovy pill.

Why? The pill will be available at six dose levels for between $149 and $349 a month for patients who buy it without using insurance (about the same price as Wegovy). But it can be taken with or without food at any time of day, whereas patients must take the Wegovy pill in the morning, on an empty stomach. Medicare is expected to soon cover the pill for some patients, at a co-pay of $50 a month, and experts expect that some private insurance plans will also cover it.

There’s obviously a huge untapped market of people who would favor a pill over injections. Many people don’t like needles. Others don’t view their weight as problematic enough to warrant an injection, but might find a pill simpler and more palatable. However, the pill versions tend to lead to less weight loss than the weekly injections—a gap that could make them less appealing to patients.

 
Dig Deeper:
 
The National Academy of Medicine has a full breakdown of GLP-1 drugs and how they work in the body.

Trump Asks Americans to Stick With Him on War

 

He says U.S. will bomb Iran “back to stone ages” over next 2-3 weeks

During his first primetime address to the nation to discuss the war with Iran, President Donald Trump on Wednesday sought to reassure (or maybe convince) Americans that the operation was necessary and will soon wrap up, as gas prices rise and foreign leaders grapple with the conflicts fallout.

In a 19-minute address, he said the U.S. would hit Iran “extremely hard over the next two to three weeks,” bombing the country “back to the stone ages where they belong.” Although the U.S. and Israeli militaries have destroyed many of Iran’s ballistic missiles and launchers in airstrikes, Iran continues to fire missiles in the region. Still, Trump described the military action as a major success and called on Americans, who are uneasy about its costs, to keep things in perspective.

Are negotiations still going on? Apparently so. The U.S. has told Tehran, through mediators, that it is interested in a ceasefire in exchange for the reopening of the Strait of Hormuz. Also, Trump appeared to back away from plans to dispatch special operations forces to seize highly enriched uranium at Iran's nuclear sites that the U.S. had bombed last year and also attacked in this war. But the speech publicly laid out a darker scenario for Iran and the global economy: the U.S. could leave the key strait closed and bomb Iran's civilian infrastructure before concluding the war.

 
Meanwhile:
 
Trump’s approval rating on the economy hits a new low.

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Is Your Gmail Username Embarrassing?

 

Because the company is finally letting us change it

Big news for people who picked their Gmail username as teenagers: Google is finally letting some Gmail users change their account’s username while retaining everything else in their account.

The ability for Gmail users to change their username was first teased by Google late last year. And now, as of this week, every Gmail user in the U.S. can officially change their username—that’s the part that comes before the “@gmail.com”—to whatever they want, as long as the new username is available. When you change your Gmail, it adds the old username as an alternate address. That should ensure that even though your account displays the new username, you’ll still receive all emails sent to the previous address.

And while most of the kinks were ironed out before launch, you might still hit a few snags when you change your Google username. Users quickly took to Reddit to express their excitement, concerns and skepticism. Some bragged that they had the foresight to be the first to claim usernames, based on their first and last names. Others joked about usernames that they claim they once had. “You have your email with ‘007’ or ‘super/ninja/hero’ or something? Well… Me too LOL,” one Redditor quipped. “Not too many names available, you have to be flexible. I’ve had my email since 2008… It needed a change! Doesn’t matter if it’s just an alias, it’s a very welcome update,” another wrote.

 
FYI:
 
Google first unveiled Gmail to the public on April 1, 2004.

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Morning Motto

Hang in there.

 

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