Tuesday, July 7th Edition
Cory Ohlendorf
Compiled and written by
CORY OHLENDORF
Valet. Editor

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Today’s Big Story

Gray Hair May Be Reversible

 

Could the tell-tale sign of aging become a thing of the past?

 

There is something a little unsettling about noticing more and more gray hairs popping up. It’s an unfortunate reminder of getting older. But new research suggests that it might not be so inevitable after all.

By using drugs that stimulate part of the immune system, researchers think they may be able to restore pigment to hair that’s gone gray to prevent or even reverse the process. The idea started with an unexpected finding in cancer patients. In a study published in JAMA Dermatology a few years ago, researchers found that 14 lung cancer patients who were treated with an immunotherapy drug also experienced the re-pigmentation of their gray hair.

Then in a different study published recently in the journal Nature, researchers from New York University’s Grossman School of Medicine examined melanocyte stem cells, or McSCs, the cells that help supply pigment-producing melanocytes. In mice, the team found that McSCs could become stranded in a part of the follicle where they no longer received the right cues to regenerate pigment cells.

Using mice as the research subjects, the team found that McSCs travel between compartments of developing hair follicles in a healthy situation. The differing compartments allow the McSCs to mature and pick up the protein that can regenerate into pigment cells and continually color hair as it grows. These McSCs shift back and forth between maturity levels over time as they continually move between the compartments, a unique aspect of the McSCs. But in some cases, the McSCs can get stuck in the hair follicle bulge compartment—that means no pigment cells, which means gray hair.

Popular Mechanics reports that a review of all the latest research found that if these McSCs could be kept mobile, or nudged out of the bulge compartment after they stall, pigment production might restart. However, it hasn’t been shown that this can be done in people. Yet. Because there are other options being tested, too. As for the next steps, researchers still need to show how much the fixed-positioning mechanism matters in human aging hair, whether McSC mobility can be restored safely, and whether that would actually bring pigment back in ordinary age-related graying.

 
FYI:

Stress can also lead to graying by causing your body to release norepinephrine, a hormone. This chemical spurs the melanocytes to leave the hair follicle, contributing to gray hair.

Iran Resumes Attacks in Strait of Hormuz

 

It will no doubt complicate negotiations with the U.S.

Iran’s Islamic Revolutionary Guard Corps fired missiles at two commercial ships near the Strait of Hormuz early Tuesday, according to a senior U.S. official, marking an escalation that threatens to complicate negotiations to end the U.S.-Iran war.

The attacks come as Iranians mourn the former supreme leader who was killed at the start of the Iran war. They also follow stepped-up threats by the powerful paramilitary force, which has been undermining talks and warning vessels not to transit the waterway using a route cleared by the U.S. military. CNN reports that a tanker was reportedly struck by an unknown projectile while traveling off Oman, near the strait.

The U.S. is likely to retaliate with strikes against Iranian targets. This is, you might recall, just after a one-week agreement between the U.S. and Iran on halting attacks in the strait expired. And last week’s round of indirect talks between the U.S. and Iran in Doha, Qatar ended without much progress on the issue of the strait. So … this is just more of the same, it sounds like.

 
Meanwhile:

Ceremonies for slain supreme leader Ayatollah Ali Khamenei are taking place in the sacred Iranian city of Qom.

Partner

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Pringle’s Latest Release Isn’t a Chip

 

It’s a potato-based hot dog bun in three classic flavors

Sure, the Fourth of July may be behind us, but that doesn’t mean that summer cookouts are coming to an end. In fact, between graduation parties, World Cup watch parties, and, of course, Labor Day weekend, backyard potlucks are only just getting started. And next week, July 15th is National Hot Dog Day. Just in time for that, famed potato chip brand Pringles is releasing new … buns?

Yeah, we were confused too. “We wanted to take something everyone knows and completely flip it into an exciting new snackable experience,” one company rep told Fast Company. “Our mission is to continually deliver the unexpected to our fans, which is why we’re reimagining ordinary, bland buns and transforming them into an extraordinarily flavorful experience fit for our iconic cans.”

The buns come in three distinct flavors: sour cream and onion, sweet and smoky BBQ, and Honey Mustard. It’s not just the flavors that are getting the Pringles treatment. The bun size is also on theme. At 7.5 inches long, each bun is made to fit the brand’s iconic cylindrical cans. One taste-tester at Mashed called them a “creative and flavorful addition” and she would “happily purchase if it becomes a regular offering.” What about you? Interested?

 
FYI:

Los Angeles residents consume more hot dogs than any other city.

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Today’s Member Extras

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Science & Space Debriefing

The Trends You Need to Know About Right Now

 

What if the universe isn’t as uniform as scientists think? Plus, researchers just built the most sophisticated synthetic cell ever created in a lab.

 

Today on

 

BEVEL creative director Josef Adamu shares the grooming products, daily rituals and small habits that help him start every day on the right note.

 
 

One of our favorite menswear brands is changing its sale strategy.

 
Tip of the Day:

Strategic summer grooming is all about trimming the unruly spots—chest, shoulders, armpits, and groin—while keeping transitions natural, so you stay clean and confident without over-shaving.

Morning Motto

Do what you can with what you have.

 

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